I've got a concept I've been developing with a friend. The central character is a ferret, and when you combine that critter with my nerd love of Doctor Who, you get this, the first Doctor of Galliferret. First, you reference a picture of William Hartnell (copyright BBC and all appropriate individuals).
From this, I worked up a sketch.
Finally, I went into Adobe Illustrator and came up with this.
There are a couple more things I plan on doing with this, but it's a good start.